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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TXNRD2
All Species:
37.88
Human Site:
Y447
Identified Species:
55.56
UniProt:
Q9NNW7
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NNW7
NP_006431.2
524
56507
Y447
G
R
D
A
S
Q
C
Y
V
K
M
V
C
L
R
Chimpanzee
Pan troglodytes
XP_001166615
481
51948
V415
G
L
S
E
E
E
A
V
A
H
H
G
Q
E
H
Rhesus Macaque
Macaca mulatta
NP_001152971
524
56314
Y447
G
R
D
A
S
Q
C
Y
V
K
M
V
C
L
R
Dog
Lupus familis
XP_850181
509
55065
Y434
E
R
D
A
S
Q
C
Y
V
K
M
V
C
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLT4
524
56434
Y447
D
R
D
A
S
Q
C
Y
I
K
M
V
C
M
R
Rat
Rattus norvegicus
Q9Z0J5
526
56406
Y449
D
R
D
A
S
Q
C
Y
I
K
M
V
C
M
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001116163
518
56137
Y441
E
R
D
A
A
Q
C
Y
I
K
M
V
C
L
R
Frog
Xenopus laevis
NP_001080052
504
54666
Y427
E
R
D
A
S
Q
C
Y
I
K
I
I
C
L
R
Zebra Danio
Brachydanio rerio
NP_898895
602
65949
Y525
G
R
D
N
N
K
C
Y
A
K
I
I
C
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91938
596
64304
Y519
Q
K
S
V
R
Y
C
Y
L
K
A
V
A
E
R
Honey Bee
Apis mellifera
NP_001171496
537
59227
Y460
Q
K
D
V
S
N
C
Y
L
K
V
I
A
F
R
Nematode Worm
Caenorhab. elegans
Q17745
667
74094
C588
E
R
M
D
K
D
H
C
Y
L
K
M
I
C
L
Sea Urchin
Strong. purpuratus
XP_797733
490
53044
Y415
N
K
P
A
E
Q
C
Y
I
K
A
I
C
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48641
499
53852
M424
G
R
Q
E
K
T
L
M
K
L
I
V
D
E
K
Baker's Yeast
Sacchar. cerevisiae
P41921
483
53422
A410
V
Y
N
S
K
F
T
A
M
Y
Y
A
M
L
S
Red Bread Mold
Neurospora crassa
Q873E8
468
50294
D403
Y
A
M
M
K
P
E
D
K
A
P
T
A
Y
K
Conservation
Percent
Protein Identity:
100
91
98.2
83.2
N.A.
84.5
82.6
N.A.
N.A.
72.9
68.6
47
N.A.
48.9
53
40.7
55.7
Protein Similarity:
100
91.2
99
91.4
N.A.
91.5
90.8
N.A.
N.A.
86
82.2
62.2
N.A.
62.4
68.5
56.2
69.8
P-Site Identity:
100
6.6
100
93.3
N.A.
80
80
N.A.
N.A.
80
73.3
46.6
N.A.
33.3
40
6.6
53.3
P-Site Similarity:
100
13.3
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
93.3
80
N.A.
46.6
66.6
13.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
32.8
34.7
Protein Similarity:
N.A.
N.A.
N.A.
51.7
53
52.4
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
26.6
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
50
7
0
7
7
13
7
13
7
19
0
0
% A
% Cys:
0
0
0
0
0
0
69
7
0
0
0
0
57
7
0
% C
% Asp:
13
0
57
7
0
7
0
7
0
0
0
0
7
0
0
% D
% Glu:
25
0
0
13
13
7
7
0
0
0
0
0
0
19
0
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% F
% Gly:
32
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
7
7
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
0
0
32
0
19
25
7
0
0
% I
% Lys:
0
19
0
0
25
7
0
0
13
69
7
0
0
0
19
% K
% Leu:
0
7
0
0
0
0
7
0
13
13
0
0
0
44
7
% L
% Met:
0
0
13
7
0
0
0
7
7
0
38
7
7
13
0
% M
% Asn:
7
0
7
7
7
7
0
0
0
0
0
0
0
7
0
% N
% Pro:
0
0
7
0
0
7
0
0
0
0
7
0
0
0
0
% P
% Gln:
13
0
7
0
0
50
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
63
0
0
7
0
0
0
0
0
0
0
0
0
63
% R
% Ser:
0
0
13
7
44
0
0
0
0
0
0
0
0
0
7
% S
% Thr:
0
0
0
0
0
7
7
0
0
0
0
7
0
0
0
% T
% Val:
7
0
0
13
0
0
0
7
19
0
7
50
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
7
0
69
7
7
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _